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Updated: Feb 1, 2026
09:26
Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
Published on: July 29, 2011
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A framework for the development of effective anti-metastatic agents
Robin L Anderson1,2,3, Theo Balasas4, Juliana Callaghan5
1Translational Breast Cancer Program, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia.
Nature Reviews. Clinical Oncology
|December 6, 2018
Summary
Effective cancer treatment requires targeting metastasis, the primary cause of cancer deaths. New strategies are needed to combat metastatic disease, independent of primary tumor response.
Area of Science:
- Oncology and Cancer Research
- Translational Medicine
Background:
- Metastasis is responsible for the majority of cancer-related deaths.
- Cancer complexity, including over 200 types and subtypes with intratumoral heterogeneity, complicates treatment efficacy.
- Limited understanding of metastatic pathophysiology compared to primary tumors hinders effective therapeutic development.
Framework:
- A collaborative Metastasis Working Group was established by Cancer Research UK and Cancer Therapeutics CRC Australia.
- The group includes diverse representation from non-profit, academic, government, industry, and regulatory sectors.
- The objective is to develop actionable recommendations for treating (micro)metastatic disease.
Implementation:
- Focus on inhibiting fundamental metastatic processes.
- Develop novel preclinical and clinical strategies specifically targeting metastasis.
- Strategies should not be solely reliant on primary tumor response.
Implications:
- Advances in understanding and treating metastatic cancer.
- Development of novel anticancer agents to prevent or delay metastatic outgrowth.
- Improved patient outcomes through targeted anti-metastasis therapies.
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