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Dermatologic lesions in a transplant population.
J H Brown1, T Hutchison, A M Kelly
1Renal Unit, Belfast City Hospital, Northern Ireland.
Transplantation
|October 1, 1988
Summary
Renal transplant recipients show a significantly higher incidence of skin lesions, including warts and hyperkeratoses. Malignant skin neoplasms occurred over four times more frequently than expected in this patient group.
Area of Science:
- Nephrology
- Dermatology
- Oncology
Background:
- Renal transplant patients often experience increased risks of certain health conditions.
- Skin neoplasia incidence is a known concern in immunosuppressed populations.
Purpose of the Study:
- To investigate the prevalence of skin lesions in renal transplant recipients.
- To quantify the incidence of skin malignancy in this cohort.
Main Methods:
- A cohort of 223 patients who received renal transplants between 1965 and 1984 were examined.
- Skin lesions were assessed for type and presence of malignancy.
Main Results:
- High rates of simple warts (24%) and hyperkeratoses (21%) were observed.
- Nine patients (4.0%) developed frank skin malignancy.
- The incidence of malignancy was more than four times the expected rate for the general population in Northern Ireland.
Conclusions:
- Renal transplant recipients exhibit a substantially elevated risk of developing skin lesions, including malignant neoplasms.
- Immunosuppression following renal transplantation is a likely contributing factor to increased skin cancer risk.