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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Related Experiment Video

Updated: Feb 1, 2026

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model
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Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model

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Adipose-derived stem cells for wound healing.

Alireza Hassanshahi1, Mohammadhossein Hassanshahi2, Samira Khabbazi2

  • 1Department of Genetics, Faculty of Basic Sciences, Islamic Azad University, Shahrekord, Iran.

Journal of Cellular Physiology
|December 6, 2018
PubMed
Summary

Adipose-derived stem cells (ASCs) show promise for improving wound healing by promoting blood vessel growth and tissue repair. This review examines ASCs

Keywords:
adipose-derived stem cellsangiogenesismesenchymal stem cellsstem cellsstromal vascular fractionwound healing

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Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Dermatology

Background:

  • Wound healing is a natural regenerative process in human skin.
  • This process is often impaired in conditions like diabetes and severe burns.
  • Various stem cell types are explored for therapeutic wound healing applications.

Purpose of the Study:

  • To review the advantages and disadvantages of different stem cells for wound healing.
  • To summarize the mechanisms by which adipose-derived stem cells (ASCs) may enhance wound repair.
  • To analyze clinical studies using ASCs for wound healing and identify limitations.

Main Methods:

  • Literature review of stem cell therapies for wound healing.
  • Analysis of studies focusing on adipose-derived stem cells (ASCs).
  • Examination of proposed mechanisms of action for ASCs in wound repair.

Main Results:

  • ASCs present fewer limitations for clinical use compared to other stem cells.
  • ASCs are hypothesized to improve wound healing via angiogenesis, immune modulation, and epithelialization.
  • Clinical applications of ASCs show potential but also highlight existing limitations.

Conclusions:

  • ASCs offer a promising therapeutic option for compromised wound healing.
  • Further research and clinical trials are needed to optimize ASC-based treatments.
  • Understanding ASC mechanisms is crucial for advancing regenerative therapies for skin repair.