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Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model
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Adipose-derived stem cells for wound healing

Alireza Hassanshahi1, Mohammadhossein Hassanshahi2, Samira Khabbazi2

  • 1Department of Genetics, Faculty of Basic Sciences, Islamic Azad University, Shahrekord, Iran.

Journal of Cellular Physiology
|December 6, 2018
PubMed

Insights

Adipose-derived stem cells (ASCs) show promise for improving wound healing by promoting blood vessel growth and tissue repair. This review examines ASCs

Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Dermatology

Background:

  • Wound healing is a natural regenerative process in human skin.
  • This process is often impaired in conditions like diabetes and severe burns.
  • Various stem cell types are explored for therapeutic wound healing applications.

Purpose of the Study:

  • To review the advantages and disadvantages of different stem cells for wound healing.
  • To summarize the mechanisms by which adipose-derived stem cells (ASCs) may enhance wound repair.
  • To analyze clinical studies using ASCs for wound healing and identify limitations.

Main Methods:

  • Literature review of stem cell therapies for wound healing.
  • Analysis of studies focusing on adipose-derived stem cells (ASCs).
  • Examination of proposed mechanisms of action for ASCs in wound repair.

Main Results:

  • ASCs present fewer limitations for clinical use compared to other stem cells.
  • ASCs are hypothesized to improve wound healing via angiogenesis, immune modulation, and epithelialization.
  • Clinical applications of ASCs show potential but also highlight existing limitations.

Conclusions:

  • ASCs offer a promising therapeutic option for compromised wound healing.
  • Further research and clinical trials are needed to optimize ASC-based treatments.
  • Understanding ASC mechanisms is crucial for advancing regenerative therapies for skin repair.
Keywords:
adipose-derived stem cellsangiogenesismesenchymal stem cellsstem cellsstromal vascular fractionwound healing

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