Related Experiment Video

Updated: Feb 1, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Permanent His bundle pacing in heart failure patients: A systematic review and meta-analysis

Zhiyong Qian1, Fengwei Zou2, Yao Wang1

  • 1Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing.

Pacing and Clinical Electrophysiology : PACE
|December 6, 2018
PubMed

Insights

His bundle pacing (HBP) shows promise for heart failure patients unresponsive to cardiac resynchronization therapy (CRT). This alternative pacing method improved left ventricular function and clinical outcomes in observational studies.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) is standard for heart failure with left ventricular (LV) dyssynchrony.
  • Approximately 30% of patients do not respond to CRT.
  • His bundle pacing (HBP) is emerging as a potential alternative for CRT-eligible patients.

Purpose of the Study:

  • To evaluate the efficacy of His bundle pacing (HBP) in patients with heart failure.
  • To assess HBP as an alternative to CRT for improving cardiac function and outcomes.

Main Methods:

  • Systematic review of PubMed and Embase databases.
  • Inclusion of 11 studies with 494 patients.
  • Extraction of data on implantation success, QRS duration, pacing thresholds, LV function, and mortality.

Main Results:

  • Successful implantation rate of 82.4% for HBP.
  • Significant improvement in LV function and clinical outcomes post-HBP (P < 0.001).
  • Mean follow-up of 23.7 months showed 5.9% heart failure hospitalization and 9.1% mortality.

Conclusions:

  • Permanent HBP demonstrates promising results in heart failure patients.
  • Further randomized controlled trials are necessary to confirm HBP efficacy.
Abstract

Keywords:
cardiac functionheart failurepermanent His bundle pacing

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