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Piecewise defined functions are mathematical models where different expressions define a function over distinct intervals of the domain. These functions are useful for representing systems with varying behaviors depending on input values.For example, the function:  uses a linear rule for inputs less than or equal to –1 and a quadratic rule for values greater than –1. Although it has two formulas, it still defines a single function.Another common type is the absolute value...
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Related Experiment Video

Updated: Feb 1, 2026

High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
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It is time to define antimicrobial never events.

Jiajun Liu1, Keith S Kaye2, Nicholas J Mercuro3

  • 11Pharmacometrics Center of Excellence,Department of Pharmacy Practice,Midwestern University Chicago College of Pharmacy,Downers Grove,Illinois.

Infection Control and Hospital Epidemiology
|December 6, 2018
PubMed
Summary
This summary is machine-generated.

Preventing inappropriate antibiotic use is crucial to combat antimicrobial resistance and patient harm. This study introduces "antibiotic never events" to define and recognize the most harmful antibiotic misuse, guiding preventative strategies.

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Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Inappropriate antibiotic use drives antimicrobial resistance (AMR) and adverse patient events.
  • Preventative strategies are essential to optimize antibiotic prescribing and minimize harm.
  • A standardized terminology is needed to address the most egregious antibiotic misuse.

Purpose of the Study:

  • To define and globally recognize the most inappropriate uses of antibiotics.
  • To introduce the concept of "antibiotic never events" for improved awareness and prevention.
  • To establish a framework for reducing avoidable harm associated with antibiotic misuse.

Main Methods:

  • Conceptual framework development.
  • Literature review on antibiotic misuse and patient harm.
  • Expert consensus on defining "antibiotic never events".

Main Results:

  • The term "antibiotic never events" is proposed to categorize the most inappropriate antibiotic administrations.
  • These events represent critical failures in antibiotic stewardship.
  • Recognition of these events facilitates targeted preventative interventions.

Conclusions:

  • Implementing preventative strategies for "antibiotic never events" is vital for combating AMR.
  • Standardized recognition of inappropriate antibiotic use can significantly reduce patient harm.
  • This initiative aims to improve global antibiotic stewardship and patient safety.