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Updated: Feb 1, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Novel cyclometallated 5-π-delocalized donor-1,3-di(2-pyridyl)benzene platinum(ii) complexes with good second-order
Mattia Fontani1, Eleonora Garoni, Alessia Colombo
1Dipartimento di Chimica dell'Università degli Studi di Milano, UdR-INSTM, via Golgi 19, I-20133, Milano, Italy. alessia.colombo@unimi.it.
Abstract:
Five new platinum(ii) complexes bearing a cyclometallated 5-π-delocalized donor-1,3-di(2-pyridyl)benzene were prepared and fully characterized. Their second-order nonlinear optical (NLO) properties were determined by the Electric-Field Induced Second Harmonic generation (EFISH) technique, working in DMF solution with an incident wavelength of 1907 nm, whereas the dipole moments were determined by Density Functional Theory (DFT) calculations. Remarkably, the platinum(ii) complex with a cyclometallated 5-guaiazulene-CH[double bond, length as m-dash]CH-1,3-di(2-pyridyl)benzene appears as a very good candidate for application in photonics, being characterized by the largest second-order NLO response. Besides, it appeared that the nature of substituents on thiophene, chosen as π-delocalized moiety in position 5 of the 1,3-di(2-pyridyl)benzene, strongly affects the NLO properties.
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