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Updated: Feb 1, 2026

Reconstitution of Membrane-Tethered Minimal Actin Cortices on Supported Lipid Bilayers
Published on: July 12, 2022
Correction: Pulling lipid tubes from supported bilayers unveils the underlying substrate contribution to the membrane
Berta Gumí-Audenis1, Luca Costa2, Lidia Ferrer-Tasies3
1Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10-12, 08028 Barcelona, Spain. migiannotti@ibecbarcelona.eu and Department of Material Science and Physical Chemistry, University of Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain and Centro de Investigación Biomédica en Red (CIBER), Instituto de Salud Carlos III, Monforte de Lemos 3-5, 28029 Madrid, Spain.
This correction clarifies findings on lipid tube pulling from supported bilayers. It emphasizes the substrate's role in membrane mechanics, crucial for understanding lipid bilayer behavior.
Area of Science:
- Biophysics
- Materials Science
- Surface Chemistry
Background:
- Supported lipid bilayers are model systems for cell membranes.
- Membrane mechanics are influenced by lipid composition and substrate interactions.
- Understanding these mechanics is vital for biomaterials and nanotechnology.
Purpose of the Study:
- To correct and clarify the original study's findings.
- To accurately present the substrate's contribution to membrane mechanics.
- To ensure precise interpretation of lipid tube pulling experiments.
Main Methods:
- Correction of data analysis and interpretation.
- Re-evaluation of lipid tube pulling experiments.
- Refined modeling of membrane-substrate interactions.
Main Results:
- The substrate significantly influences the force required to pull lipid tubes.
- Specific substrate properties dictate the observed membrane deformation.
- Revised calculations confirm the substrate's dominant role in mechanics.
Conclusions:
- The substrate's contribution to supported membrane mechanics is critical.
- Accurate modeling requires explicit consideration of substrate properties.
- This correction enhances the understanding of lipid bilayer behavior at interfaces.
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