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Injectable, Magnetically Orienting Electrospun Fiber Conduits for Neuron Guidance
Christopher D L Johnson, Debmalya Ganguly, Jonathan M Zuidema1
1Department of Chemistry and Biochemistry , University of California at San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.
ACS Applied Materials & Interfaces
|December 6, 2018
Summary
Injectable magnetic electrospun fibers guide neuron growth. These magnetically positioned scaffolds enhance neurite outgrowth and length in 3D hydrogels for neural applications.
Area of Science:
- Biomaterials Science
- Neuroscience
- Nanotechnology
Background:
- Minimally invasive biomaterials require cell guidance capabilities.
- Magnetic electrospun fibers offer in situ injection and magnetic positioning.
- Aligned fiber scaffolds provide topographical cell guidance.
Purpose of the Study:
- Develop and test magnetically responsive aligned poly-l-lactic acid electrospun fiber scaffolds for neural applications.
- Investigate the effect of iron oxide nanoparticles on fiber properties and neurite outgrowth.
- Evaluate the system as an injectable 3D scaffold for neuronal guidance.
Main Methods:
- Fabrication of magnetic aligned poly-l-lactic acid electrospun fiber scaffolds incorporating oleic acid-coated iron oxide nanoparticles.
- Assessment of fiber properties including alignment, nanotopography, and neurite outgrowth.
- Testing of injectable 3D scaffolds using dorsal root ganglion explants in collagen/fibrinogen hydrogels.
Main Results:
- Incorporation of nanoparticles increased neurite outgrowth and surface nanotopography, while reducing fiber alignment.
- Injectable magnetic fiber conduits were successfully positioned in situ using an external magnetic field.
- Aligned magnetic fibers significantly enhanced neurite extension (1.4-3x) and alignment within 3D hydrogels compared to hydrogel alone.
Conclusions:
- Magnetic electrospun fiber scaffolds are injectable and magnetically manipulable for in situ neuronal guidance.
- This injectable guidance system promotes both neurite alignment and length within hydrogel scaffolds.
- The developed system shows promise for minimally invasive neural tissue engineering applications.
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