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Related Experiment Video

Updated: Feb 1, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Injectable, Magnetically Orienting Electrospun Fiber Conduits for Neuron Guidance.

Christopher D L Johnson, Debmalya Ganguly, Jonathan M Zuidema¹

¹Department of Chemistry and Biochemistry , University of California at San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.

ACS Applied Materials & Interfaces

|December 6, 2018

Summary

Injectable magnetic electrospun fibers guide neuron growth. These magnetically positioned scaffolds enhance neurite outgrowth and length in 3D hydrogels for neural applications.

Keywords:

dorsal root ganglia injectable magnetic electrospun fibers poly-l-lactic acid spinal cord injury topographical guidance

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Last Updated: Feb 1, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

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Published on: April 19, 2015

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

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Published on: January 8, 2013

Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

Published on: June 27, 2018

Area of Science:

Biomaterials Science
Neuroscience
Nanotechnology

Background:

Minimally invasive biomaterials require cell guidance capabilities.
Magnetic electrospun fibers offer in situ injection and magnetic positioning.
Aligned fiber scaffolds provide topographical cell guidance.

Purpose of the Study:

Develop and test magnetically responsive aligned poly-l-lactic acid electrospun fiber scaffolds for neural applications.
Investigate the effect of iron oxide nanoparticles on fiber properties and neurite outgrowth.
Evaluate the system as an injectable 3D scaffold for neuronal guidance.

Main Methods:

Fabrication of magnetic aligned poly-l-lactic acid electrospun fiber scaffolds incorporating oleic acid-coated iron oxide nanoparticles.
Assessment of fiber properties including alignment, nanotopography, and neurite outgrowth.
Testing of injectable 3D scaffolds using dorsal root ganglion explants in collagen/fibrinogen hydrogels.

Main Results:

Incorporation of nanoparticles increased neurite outgrowth and surface nanotopography, while reducing fiber alignment.
Injectable magnetic fiber conduits were successfully positioned in situ using an external magnetic field.
Aligned magnetic fibers significantly enhanced neurite extension (1.4-3x) and alignment within 3D hydrogels compared to hydrogel alone.

Conclusions:

Magnetic electrospun fiber scaffolds are injectable and magnetically manipulable for in situ neuronal guidance.
This injectable guidance system promotes both neurite alignment and length within hydrogel scaffolds.
The developed system shows promise for minimally invasive neural tissue engineering applications.