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Ischemic stroke and infectious diseases in low-income and middle-income countries

Breno Franco Silveira Fernandes1, Paulo Caramelli1,2

  • 1Serviço de Neurologia, Hospital das Clínicas da Universidade Federal de Minas Gerais/EBSERH.

Current Opinion in Neurology
|December 6, 2018
PubMed
Abstract

Insights

Infections are a significant factor in stroke, particularly in low-income countries. Understanding this link is crucial for managing stroke risk and outcomes globally.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Global Health

Background:

  • Stroke is a leading cause of death and disability worldwide, disproportionately affecting low- and middle-income countries (LMICs).
  • Infectious diseases remain a major health challenge in LMICs, potentially contributing to a higher incidence of stroke in these regions.
  • The relationship between infection and stroke is bidirectional, with infections acting as both risk factors and consequences.

Purpose of the Study:

  • To examine the intricate relationship between stroke and infection.
  • To focus on prevalent infections in LMICs and their impact on stroke.
  • To highlight specific infectious etiologies of stroke relevant to global health.

Main Methods:

  • Review of current literature on stroke and infection.
  • Analysis of infectious diseases that directly cause stroke.
  • Consideration of infections as stroke triggers and post-stroke complications.

Main Results:

  • Common infections can trigger acute stroke via various mechanisms.
  • Specific infections like Chagas disease, neurosyphilis, tuberculous meningitis, and neurocysticercosis are direct causes of stroke.
  • Infection is a frequent complication following stroke, significantly impacting patient outcomes.

Conclusions:

  • Infectious diseases and stroke are prevalent issues in LMICs.
  • Further research is needed to fully understand the impact of infections on stroke burden, especially where data is limited.
  • Recognizing and managing infection-related stroke is critical for improving global health outcomes.

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