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Imaging Review of Common and Rare Causes of Stroke in Children
Giulio Zuccoli1, Charles Fitz1, Stephanie Greene2
1Section of Neuroradiology.
Insights
Pediatric stroke, a significant cause of child mortality, involves diverse etiologies. Early diagnosis using multimodal neuroimaging is crucial for effective management of vascular brain injury in children.
Area of Science:
- Neurology
- Pediatrics
- Radiology
Background:
- Vascular injury is a critical factor in pediatric mortality and morbidity.
- Pediatric vascular brain injury is often underdiagnosed due to lower suspicion compared to adults.
Purpose of the Study:
- To review common and rare causes of pediatric stroke.
- To correlate neuroimaging findings with clinical presentations.
- To emphasize the role of multimodal neuroimaging in diagnosis.
Main Methods:
- Literature review of pediatric stroke etiologies.
- Analysis of neuroimaging findings in pediatric stroke.
- Discussion of clinical mimics and diagnostic approaches.
Main Results:
- Identified cardioembolic, viral, autoimmune, post-traumatic, and genetic causes of pediatric stroke.
- Provided neuroimaging correlates for clinical stroke mimics.
- Highlighted the utility of multimodal noninvasive neuroimaging.
Conclusions:
- Multimodal noninvasive neuroimaging is key for early pediatric stroke diagnosis.
- A structured approach aids differential diagnosis for clinicians.
- Increased awareness and diagnostic tools improve outcomes for pediatric vascular brain injury.
Abstract:
Vascular injury is increasingly recognized as an important cause of mortality and morbidity in children (29 days to 18 years of age). Since vascular brain injury in children appears to be less common than in adults, the index of suspicion for vascular brain injury is usually lower. In this review article, we describe frequent and rare conditions underlying pediatric stroke including cardioembolic, viral, autoimmune, post-traumatic, and genetic etiologies. Furthermore, we provide a neuroimaging correlate for clinical mimics of pediatric stroke. This review highlights the role of multimodal noninvasive neuroimaging in the early diagnosis of pediatric stroke, providing a problem-solving approach to the differential diagnosis for the neuroradiologist, emergency room physician, and neurologist.
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