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Published on: September 14, 2017
Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)-H functionalization enabled
Surajit Haldar1, Chandan K Jana
1Department of Chemistry, Indian Institute of Technology Guwahati, 781039, India. ckjana@iitg.ac.in.
Abstract:
An unprecedented method for the direct arylation and heteroarylation of tetrahydroisoquinolines under metal and oxidant free conditions is reported. The arylation reactions occurred via a C(sp3)-H functionalization enabled three component condensation of tetrahydroisoquinolines, 9-fluorenone imine, and arenes without involving a pre-functionalization/pre-derivatization step. A wide range of arenes and heteroarenes participated in the reaction to provide structurally diverse arylated tetrahydroisoquinolines with good to excellent yields.
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