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Developmental changes in resting-state functional networks among individuals with and without internalizing
Katie L Burkhouse1, Jonathan P Stange1, Rachel H Jacobs1
1Department of Psychiatry, University of Illinois-Chicago, Chicago, USA.
Depression and Anxiety
|December 6, 2018
Summary
Brain network connectivity in typically developing individuals strengthens with age, while those with internalizing disorders show altered patterns. These findings inform developmental treatments for conditions like anxiety and depression.
Area of Science:
- Neuroscience
- Developmental Psychology
- Psychiatry
Background:
- Intrinsic connectivity networks (ICNs) like the cognitive control network (CCN), default mode network (DMN), and salience and emotional network (SEN) are crucial for cognitive-affective processing.
- Previous research on ICN development has limitations in age range and network isolation.
- The impact of internalizing psychopathologies (IPs) on age-related brain network changes remains unclear.
Purpose of the Study:
- To map the normative development of CCN, DMN, and SEN across a wide age range (7-29 years) in typically developing (TD) individuals.
- To investigate how age influences brain network connectivity differences between TD individuals and those with a history of IPs.
Main Methods:
- Studied 97 typically developing individuals and 136 patients with IPs, aged 7-29 years.
- Analyzed functional connectivity within and between the CCN, DMN, and SEN.
- Compared age-related changes in network connectivity between TD and IP groups.
Main Results:
- In TD individuals, DMN and CCN connectivity increased with age; SEN connectivity to the ventromedial prefrontal cortex decreased.
- IP group showed increased CCN-cerebellum and SEN-caudate connectivity compared to TD individuals.
- IP group exhibited decreased SEN-medial frontal gyrus connectivity from adolescence to adulthood.
Conclusions:
- Identified distinct age-related brain network alterations in TD individuals versus those with IPs.
- Findings highlight potential neurodevelopmental targets for mechanism-based treatments for internalizing disorders.
- Results suggest treatment approaches may need to be tailored to developmental stages.
Keywords:
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