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A Protocol for Analyzing Hepatitis C Virus Replication
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A Protocol for Analyzing Hepatitis C Virus Replication

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Fluctuations in serological hepatitis C virus levels in HIV patients

Vanessa Cristina Martins Silva1, Samira Julien Calux1, Marcilio Figueiredo Lemos1

  • 1Laboratório de Hepatites Virais, Centro de Virologia, Instituto Adolfo Lutz, São Paulo, SP, Brasil.

Revista Da Sociedade Brasileira De Medicina Tropical
|December 6, 2018
PubMed

Insights

Coinfection with Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is common. Periodic monitoring of HCV serology is crucial for coinfected patients due to detected fluctuations in HCV levels.

Area of Science:

  • Infectious Diseases
  • Virology
  • Immunology

Background:

  • Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) share transmission routes, leading to high coinfection rates.
  • Understanding serological fluctuations in coinfected individuals is vital for patient management.

Purpose of the Study:

  • To investigate fluctuations in serological Hepatitis C virus (HCV) levels among patients with human immunodeficiency virus (HIV).
  • To compare serological HCV markers in coinfected patients versus HCV-monoinfected individuals.

Main Methods:

  • Analysis of blood samples from 147 HIV/AIDS patients and 22 HCV-monoinfected patients in São Paulo.
  • Serological testing for HCV antibodies, followed by real-time PCR for viral RNA quantification and sequencing.

Main Results:

  • 13.6% of the HIV-positive study population was coinfected with HCV.
  • Fluctuations in anti-HCV serological markers were observed in 20% of coinfected patients during follow-up.
  • HCV viral load was detected in 9.5% of HIV patients, indicating active infection.

Conclusions:

  • The study provides critical clinical data for public health professionals managing HCV/HIV coinfections.
  • Regular monitoring of HCV serological markers is essential for effective clinical care of coinfected patients.
Abstract

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