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Published on: November 3, 2010
Nonequilibrium Energetics of Molecular Motor Kinesin
Takayuki Ariga1,2, Michio Tomishige3, Daisuke Mizuno2
1Graduate School of Medicine, Yamaguchi University, Yamaguchi 755-8505, Japan.
Abstract:
Nonequilibrium energetics of single molecule translational motor kinesin was investigated by measuring heat dissipation from the violation of the fluctuation-response relation of a probe attached to the motor using optical tweezers. The sum of the dissipation and work did not amount to the input free energy change, indicating large hidden dissipation exists. Possible sources of the hidden dissipation were explored by analyzing the Langevin dynamics of the probe, which incorporates the two-state Markov stepper as a kinesin model. We conclude that internal dissipation is dominant.
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