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Updated: Feb 1, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
Published on: December 18, 2017
Guiding COMPASS: Dpy-30 Positions SET1/MLL Epigenetic Signaling
David Dilworth1, Cheryl H Arrowsmith2
1Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Abstract:
In this issue of Structure, Haddad et al. (2018) solve the high-resolution trimeric crystal structure of human COMPASS-like components Dpy-30 and Ash2L (2:1) to unravel an uncharacterized interaction surface required for competent H3K4 methylation in cells and clarify Dpy-30's role in the allosteric regulation of KMT2 enzymes.
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