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Culture of Bladder Cancer Organoids as Precision Medicine Tools
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The Role of Glucocorticoid Receptor Signaling in Bladder Cancer Progression

Hiroki Ide1,2, Satoshi Inoue3,4, Hiroshi Miyamoto5,6,7

  • 1Department of Urology, Keio University School of Medicine, Tokyo 160-8582, Japan. h-ide@fc4.so-net.ne.jp.

Cancers
|December 7, 2018
PubMed

Insights

Glucocorticoid receptor signaling inhibits tumor growth. This review explores its role in bladder cancer progression and potential therapeutic mechanisms, linking receptor levels to patient prognosis.

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • Glucocorticoid receptor (GR) signaling is known to inhibit various tumor types.
  • Glucocorticoids like dexamethasone and prednisone are used for hematological malignancies and prostate cancer.
  • The role of GR signaling in bladder cancer progression is not well understood.

Purpose of the Study:

  • To review the involvement of GR signaling in urothelial cancer outgrowth.
  • To highlight potential molecular mechanisms of GR action in bladder cancer.
  • To discuss molecules and pathways modulating GR activity in bladder cancer cells.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of data on GR expression and patient prognosis in bladder cancer.
  • Synthesis of information on molecular mechanisms and signaling pathways.

Main Results:

  • Emerging evidence suggests unique functions of GR signaling in urothelial cancer cells.
  • GR expression levels are significantly associated with bladder cancer patient prognosis.
  • GR signaling may play a complex role in urothelial tumor outgrowth.

Conclusions:

  • GR-mediated signaling is implicated in bladder cancer progression.
  • Understanding these mechanisms could reveal novel therapeutic strategies.
  • Further research is needed to fully elucidate the role of GR in bladder cancer.
Keywords:
androgen receptorcompound Adexamethasoneestrogen receptorglucocorticoid receptorglucocorticoidstransactivationtransrepressiontumor progressionurothelial cancer

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