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Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC
Marc A Schneider1,2, Thomas Muley3,4, Rebecca Weber5,6
1Translational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, Germany. marc.schneider@med.uni-heidelberg.de.
Abstract:
A major part of non-small cell lung cancer (NSCLC) patients treated with mono- or multimodal concept develop therapy resistance. Despite the abundance of biomarkers investigated in the past, there is still a need for valid NSCLC biomarkers. Glycodelin, an immunosuppressive endometrial protein, has been shown to be also expressed in NSCLC. Here, we investigated its potential as a biomarker in metastatic and advanced stage NSCLC. Glycodelin gene and protein expression were measured in 28 therapy-naïve resected tumors as well as in corresponding brain (n = 16) and adrenal gland (n = 12) metastasis by qPCR and IHC. Moreover, we correlated glycodelin gene expression of cryoconserved therapy-naïve biopsies (n = 55) of advanced stage patients with glycodelin serum concentrations and patient survival. Using follow-up samples of the patients, we monitored glycodelin serum concentrations during therapy. Glycodelin expression correlated between primary tumor and distant metastases within the same patients. The gene expression of glycodelin in therapy-naïve biopsies also correlated with the serum concentrations of the patients (r = 0.60). Patients with elevated serum concentrations showed a tendency in lower overall survival (p = 0.088) and measuring of glycodelin indicated a progression of the disease earlier compared to clinical diagnostic. Taken together, we demonstrate that glycodelin is a promising prognostic and follow-up biomarker for metastatic and advanced NSCLC.
Insights
Glycodelin shows promise as a biomarker for non-small cell lung cancer (NSCLC). Measuring glycodelin levels can help predict patient survival and monitor disease progression in advanced NSCLC.
Area of Science:
- Oncology
- Biomarker Discovery
- Molecular Diagnostics
Background:
- Non-small cell lung cancer (NSCLC) frequently develops therapy resistance, necessitating novel biomarkers.
- Existing NSCLC biomarkers are insufficient, highlighting the need for new diagnostic tools.
- Glycodelin, an immunosuppressive protein, is expressed in NSCLC and warrants investigation as a potential biomarker.
Purpose of the Study:
- To investigate glycodelin's potential as a biomarker in metastatic and advanced NSCLC.
- To correlate glycodelin expression in tumors and serum with patient outcomes.
- To assess glycodelin's utility for monitoring disease progression during therapy.
Main Methods:
- Quantitative PCR (qPCR) and immunohistochemistry (IHC) to measure glycodelin gene and protein expression in tumors and metastases.
- Correlation analysis of glycodelin gene expression in therapy-naïve biopsies with serum concentrations and patient survival.
- Monitoring of serum glycodelin concentrations during therapy using follow-up samples.
Main Results:
- Glycodelin expression was consistent between primary tumors and distant metastases.
- A significant correlation (r=0.60) was observed between glycodelin gene expression in biopsies and serum concentrations.
- Elevated serum glycodelin levels showed a trend towards lower overall survival and indicated earlier disease progression.
Conclusions:
- Glycodelin is a promising prognostic biomarker for metastatic and advanced NSCLC.
- Serum glycodelin levels can serve as a valuable follow-up marker for disease monitoring.
- Glycodelin's expression and concentration correlate with disease status and patient survival in NSCLC.
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