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The lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy
Paweł Woźniak1, Bogdan Kontek2, Waldemar Różański1
12nd Department of Urology, Medical University of Łódź, Pabianicka 62, 93-513 Łódź, Poland.
Aim:
To evaluate the level of lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy (ESWL).
Materials & Methods:
Isoprostane concentration (8-isoPGF2α) was measured in urine, and thiobarbituric acid reactive substance production in serum and erythrocytes. In addition, the concentrations of selected compounds (uric acid, glucose and creatinine) were measured in serum.
Results:
The patients (before and after ESWL) demonstrated significantly higher levels of two different biomarkers of lipid peroxidation compared with the control group. A correlation was identified between increased amounts of uric acid and biomarkers of lipid peroxidation in patients with nephrolithiasis, both before and after ESWL.
Conclusion:
Uric acid may be associated with lipid peroxidation in patients with nephrolithiasis.
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