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Evaluating Transfer of Modafinil Into Human Milk During Lactation: A Case Report

Sanjay Aurora1, Nadia Aurora2, Palika Datta3

  • 1Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|December 7, 2018
PubMed

We present a case of a 27-year-old woman in whom idiopathic hypersomnolence was diagnosed in adolescence with adequate symptomatic control on daily dosage of 250 mg of modafinil. She maintained this dosage throughout her pregnancy and during the peripartum period, but did not breastfeed her newborn because of a lack of information on the transmission of modafinil in human breast milk. Samples of her breast milk were obtained at various times over a 24-hour period and analyzed using liquid chromatography mass spectrometry. The relative infant dose was calculated to be 5.3%, below the threshold of concern for drug passage via breast milk. This is the first reported case of modafinil transfer into human breast milk. Given the drug's use in a variety of sleep disorders, the results of this case can be used to advise breastfeeding mothers prescribed modafinil.

Keywords:
armodafinilhuman breast milkidiopathic hypersomniamodafinil

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