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Related Experiment Video

Updated: Jul 28, 2026

Orthotopic Hind Limb Transplantation in the Mouse
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Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Modified Masquelet's technique with nail and allograft: A case report.

F Niccolai1, L Di Mento1, M Mocchi1

  • 1Department of Traumatology, IRCCS Humanitas Research Hospital, Milano, Italy.

Injury
|December 7, 2018
PubMed
Summary

This study presents a modified Masquelet technique for treating large bone defects, successfully healing a 6cm femur gap in a young patient. The modified approach enabled early weight-bearing and accelerated functional recovery, demonstrating its potential in orthopaedic trauma surgery.

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Area of Science:

  • Orthopaedic Trauma Surgery
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Large bone defects pose significant challenges in orthopaedic trauma surgery.
  • The Masquelet technique is a common method for addressing these defects.
  • Septic pseudoarthrosis requires specialized treatment approaches.

Observation:

  • A modified Masquelet technique was employed to treat a 6cm proximal femur bone gap in an 18-year-old male with septic pseudoarthrosis.
  • The procedure involved a two-stage approach: initial placement of a hollow antibiotic spacer and intramedullary nail, followed by bone grafting and a new nail.
  • The bone graft comprised both allologous and autologous bone graft material.

Findings:

  • The modified technique facilitated immediate partial weight-bearing post-operatively.
Keywords:
Bone allograftInfectionIntramedullary nailMasqueletNon-union

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  • The patient achieved complete weight-bearing within 3 months.
  • Fracture healing was uneventful one year after the procedure.
  • Implications:

    • This modified Masquelet technique allows for safe, immediate weight-bearing, potentially accelerating functional recovery in patients with large bone defects.
    • The combined use of antibiotic spacers, bone allografts, and autografts shows promise for complex fracture management.
    • Further research is warranted to standardize this combined technique for broader clinical application.