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Reduced corin enzyme expression in patients with left ventricular (LV) dysfunction contributes to higher levels of unprocessed pro-brain natriuretic peptide (proBNP), potentially explaining BNP resistance in these individuals.

Keywords:
BNPBrain natriuretic peptideCorinHeart failureLeft ventricular function

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Area of Science:

  • Cardiology
  • Biochemistry
  • Molecular Biology

Background:

  • Circulating B-type natriuretic peptide (BNP) levels are key indicators of left ventricular (LV) dysfunction.
  • Corin, a cardiac serine protease, is crucial for cleaving the pro-brain natriuretic peptide (proBNP) precursor into active BNP.

Purpose of the Study:

  • To investigate the association between corin expression and circulating BNP levels in patients with LV dysfunction.
  • To explore the role of corin in the processing of proBNP in idiopathic dilated cardiomyopathy (DCMP).

Main Methods:

  • Quantitative reverse transcription-polymerase chain reaction was used to measure myocardial expression of NPPB (encoding BNP) and corin.
  • Plasma proBNP and BNP levels were quantified, and the proBNP/BNP ratio was calculated.
  • Comparison was made between 25 DCMP patients and 44 heart transplant recipients.

Main Results:

  • DCMP patients exhibited poorer hemodynamics and elevated plasma proBNP and BNP levels compared to transplant recipients.
  • Myocardial corin expression was significantly lower in DCMP patients, correlating with NPPB expression, ejection fraction, and LV filling pressures.
  • Plasma proBNP/BNP levels showed an inverse correlation with myocardial corin expression.

Conclusions:

  • Decreased myocardial corin expression in DCMP patients is linked to higher circulating proBNP levels.
  • This reduced corin activity may contribute to the observed relative resistance to BNP in patients with LV dysfunction.