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Published on: October 31, 2025
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Histological chorioamnionitis and developmental outcomes in very preterm infants
Tobias Strunk1,2, Catherine Campbell3,4, David Burgner5,6,7
1Centre for Neonatal Research and Education, School of Medicine, University of Western Australia, Perth, WA, Australia. tobias.strunk@health.wa.gov.au.
Summary
Histological chorioamnionitis (HCA) in premature infants is linked to neonatal complications but not long-term neurodevelopmental issues. This study found no association between HCA exposure and cognitive, language, or motor delays at age two.
Area of Science:
- Neonatal research
- Perinatal medicine
- Developmental pediatrics
Background:
- Histological chorioamnionitis (HCA) is a placental inflammation.
- HCA is associated with adverse neonatal outcomes.
- The impact of HCA on long-term neurodevelopment in extremely preterm infants requires further characterization.
Purpose of the Study:
- To investigate the association between histological chorioamnionitis (HCA) and neurodevelopmental outcomes.
- To assess cognitive, language, and motor development in children born before 30 weeks gestation.
- To determine if HCA exposure influences neurodevelopmental trajectories.
Main Methods:
- Retrospective cohort study of infants born between 2006-2012.
- Inclusion criteria: placental histopathology, neonatal data, and Bayley-III assessment at 2 years.
- Logistic regression models adjusted for gestational age, sex, small for gestational age, and brain injury.
Main Results:
- Of 1353 infants, 708 had complete data for neurodevelopmental assessment.
- HCA exposure was associated with increased risk of neonatal adverse outcomes.
- Stage of HCA correlated with low Apgar score and early-onset sepsis.
- No significant association was found between HCA exposure and neurodevelopmental outcomes in adjusted models.
Conclusions:
- Histological chorioamnionitis (HCA) is linked to neonatal morbidity.
- Higher stages of HCA correlate with specific neonatal complications.
- HCA exposure, even at higher stages, was not associated with adverse neurodevelopmental outcomes at 2 years of age.
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