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Related Experiment Video

Updated: Feb 1, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Cell-based immunotherapy approaches for multiple myeloma.

Katharina Kriegsmann1, Mark Kriegsmann2, Martin Cremer3

  • 1Department of Hematology, Oncology and Rheumatology, Heidelberg University, Heidelberg, Germany. katharina.kriegsmann@med.uni-heidelberg.de.

British Journal of Cancer
|December 7, 2018
PubMed
Summary
This summary is machine-generated.

Chimeric antigen receptor (CAR) T-cell therapy shows promise for treating multiple myeloma (MM), a currently incurable cancer. Early clinical trials indicate high response rates, suggesting CAR T-cells may become a standard MM treatment.

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Area of Science:

  • Immunotherapy
  • Hematologic Oncology
  • Cellular Therapy

Background:

  • Multiple myeloma (MM) remains incurable despite novel therapies, necessitating new treatment strategies.
  • Chimeric antigen receptor (CAR) T cells are engineered T cells targeting tumor antigens, offering potential for long-lasting anti-myeloma immunity.

Purpose of the Study:

  • To review the feasibility and safety of CAR T-cell therapy in multiple myeloma.
  • To discuss emerging cellular therapies including CAR natural killer (NK) cells and engineered T cell receptors (TCRs) for MM treatment.

Main Methods:

  • Review of preclinical studies and early-phase clinical trials involving CAR T-cell therapy for MM.
  • Examination of data from trials targeting BCMA, CD19, CD38, and kappa light chain.

Main Results:

  • Promising preliminary results with high response rates in Phase I trials for relapsed/refractory MM.
  • Preclinical success with CD38 and SLAMF7 CAR T cells warrants further investigation.

Conclusions:

  • CAR T-cell therapy demonstrates significant potential as a future standard treatment for multiple myeloma.
  • Ongoing research into CAR NK cells and TCR-based therapies may offer alternative or complementary treatment options.