Related Experiment Video
Updated: Feb 1, 2026
09:51
Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience
Published on: December 4, 2023
1.7K
Management Of Synchronous Krukenberg Tumors From Gastric Cancer: a Single-center Experience
Dingding Yan1, Yian Du2, Gaiguo Dai2
1Department of Gynecologic oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Journal of Cancer
|December 7, 2018
Summary
Metastasectomy combined with chemotherapy significantly improves survival for gastric cancer patients with ovarian metastases (Krukenberg tumors). Key prognostic factors include the surgery itself, tumor characteristics like signet ring cells, and hormone receptor expression.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- The prognostic impact of metastasectomy in gastric cancer patients with ovarian metastases (Krukenberg tumors) remains unclear.
- This study investigates the survival benefit of combining metastasectomy with chemotherapy for synchronous Krukenberg tumors originating from gastric cancer.
Purpose of the Study:
- To evaluate the survival advantage of metastasectomy plus chemotherapy versus chemotherapy alone in patients with synchronous Krukenberg tumors of gastric origin.
- To identify independent prognostic factors influencing overall survival in this patient cohort.
Main Methods:
- Retrospective analysis of 103 patients diagnosed with synchronous Krukenberg tumors from gastric cancer between December 2004 and December 2015.
- Patients were divided into two groups: metastasectomy group (metastasectomy + chemotherapy) and non-metastasectomy group (chemotherapy alone).
- Clinicopathological data, treatment records, and survival outcomes were analyzed to identify predictors of overall survival.
Main Results:
- Overall survival (OS) was significantly longer in the metastasectomy group (18.9 months) compared to the non-metastasectomy group (12.4 months) (P<0.001).
- Metastasectomy was an independent predictor of improved OS (HR 0.486).
- Other independent predictors of OS included signet ring cells (HR 1.938), peritoneal carcinomatosis (HR 1.934), estrogen receptor-β (ER-β) expression (HR 0.404), and progesterone receptor (PR) expression (HR 0.496).
Conclusions:
- Metastasectomy combined with chemotherapy is associated with a survival benefit for patients presenting with synchronous Krukenberg tumors from gastric cancer.
- Metastasectomy, ER-β and PR expression, peritoneal carcinomatosis, and the presence of signet ring cells are identified as independent prognostic factors for survival.
- Further prospective studies are recommended to validate these findings.
Related Concept Videos
02:33Lattice Centering and Coordination Number
11.6K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
Types of Unit Cells
Imagine taking a large number of identical...
11.6K
01:16Gastric Motility
3.2K
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
3.2K
02:40Cancer Stem Cells and Tumor Maintenance
6.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K
01:16Gastric Emptying
3.7K
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
3.7K
00:58Center of Gravity
6.7K
The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
6.7K
01:15Center of Gravity
2.2K
The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...
To determine its location, the principle of moments can be utilized by dividing the object into...
2.2K