Related Experiment Video
Updated: Feb 1, 2026

Diagnostic Ultrasound Imaging of Mouse Diaphragm Function
Published on: April 21, 2014
Porous diaphragm syndrome with recurrent thymoma
Takayo Ota1, Yoshikazu Hasegawa1, Takafumi Okabe2
1Department of Medical Oncology Izumi City General Hospital Izumi Japan.
Abstract:
Porous diaphragm syndrome describes a defect in the diaphragm in which substances pass from the peritoneal cavity to the pleural space. Defects may be congenital or acquired. Acquired defects are caused by the thinning and eventual splitting of collagen fibres in the tendinous part of the diaphragm. We report a case of porous diaphragm syndrome with recurrent thymoma that presented with massive ascites. Increasing intra-abdominal pressure by ascites and diaphragmatic thinning due to malnutrition by malignancies resulted in the formation of an artificial hole. Thoracentesis changed the balance of hydrostatic pressure, which initiated the influx of a large volume of ascites to the pleural cavity through a hole in the diaphragm.
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