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Promising Long-Term Outcomes After Pelvic Exenteration.
Yakup Kulu1, Arianeb Mehrabi2, Elias Khajeh2
1Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany. yakup.kulu@med.uni-heidelberg.de.
Annals of Surgical Oncology
|December 7, 2018
Summary
Pelvic exenteration (PE) offers good long-term survival, even with extrapelvic disease. Recurrent disease impacts oncologic outcomes, but long-term survival remains achievable for these patients.
Area of Science:
- Oncology
- Surgical Oncology
- Pelvic Surgery
Background:
- Pelvic exenteration (PE) is a complex surgical procedure with limited and conflicting outcome data.
- Evaluating PE outcomes for primary and recurrent pelvic malignancies is crucial.
Purpose of the Study:
- To analyze patient outcomes after pelvic exenteration (PE).
- To identify prognostic indicators for survival and recurrence in patients undergoing PE.
Main Methods:
- Retrospective analysis of 187 patients undergoing PE between 2001 and 2016.
- Evaluation of perioperative outcomes, survival rates, and recurrence patterns.
- Uni- and multivariate analyses to determine prognostic factors.
Main Results:
- 10-year survival was 63.5% for primary tumors and 20.9% for recurrent disease (p=0.02).
- Extrapelvic disease with curative resection had a 10-year survival of 37%.
- Poor survival predictors included margin positivity, prolonged surgery (>7h), and recurrent disease.
Conclusions:
- Pelvic exenteration demonstrates favorable long-term results, including for patients with extrapelvic disease.
- Recurrent disease is associated with poorer oncologic outcomes compared to primary disease.
- Long-term survival is attainable even in patients with recurrent pelvic malignancies following PE.
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