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The effect of chronic kidney disease on lipid metabolism

Neris Dincer1, Tuncay Dagel2, Baris Afsar3

  • 1Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.

International Urology and Nephrology
|December 7, 2018
PubMed

Insights

Cardiovascular disease is a major risk for chronic kidney disease (CKD) patients. CKD alters lipoprotein profiles, increasing cardiovascular risk, necessitating targeted therapies beyond statins.

Area of Science:

  • Nephrology
  • Cardiology
  • Metabolic Disorders

Background:

  • Cardiovascular diseases (CVD) are the leading cause of mortality in chronic kidney disease (CKD) patients.
  • CKD and CVD share a bidirectional relationship, exacerbating each other's severity.
  • Dyslipidemia, alongside diabetes and hypertension, is a primary driver of CVD in CKD populations.

Purpose of the Study:

  • To review the impact of CKD on lipoprotein profiles.
  • To explore how these alterations influence cardiovascular risk.
  • To discuss potential novel therapeutic strategies for managing dyslipidemia in CKD.

Main Methods:

  • Literature review focusing on the relationship between CKD and dyslipidemia.
  • Analysis of changes in lipoprotein composition in CKD patients.
  • Examination of current and potential therapeutic interventions.

Main Results:

  • CKD significantly alters the lipoprotein profile, characterized by increased triglycerides, very low-density lipoprotein (VLDL), and oxidized low-density lipoprotein (oxLDL), and decreased high-density lipoprotein (HDL).
  • These alterations, termed the "dyslipidemic profile" of CKD, contribute to heightened cardiovascular risk.
  • Current treatments primarily involve statins, tailored to kidney function.

Conclusions:

  • Understanding the "dyslipidemic profile" in CKD is crucial for developing effective cardiovascular disease prevention strategies.
  • Novel therapeutic approaches targeting specific lipoprotein alterations in CKD are warranted.
  • Personalized treatment strategies considering kidney function and lipoprotein abnormalities are essential.

Keywords:
CholesterolChronic kidney diseaseHDLLDLPCSK9Triglycerides

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