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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
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3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer
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3D Printing Technology in Drug Delivery: Recent Progress and Application.

Sabna Kotta1, Anroop Nair2, Nimer Alsabeelah1

  • 1College of Pharmacy and Dentistry, Buraydah Private Colleges, Buraydah, Saudi Arabia.

Current Pharmaceutical Design
|December 7, 2018
PubMed
Summary

Three-dimensional (3D) printing offers a flexible and transformative approach to pharmaceutical manufacturing, enabling personalized drug dosing and complex release profiles. This technology is poised to revolutionize drug delivery systems with tailored patient-compatible formulations.

Keywords:
3D printed polypill3D printingfused depositionhot-melt extrusionpersonalized drug dosingstereolithographic 3D printing.

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Area of Science:

  • Pharmaceutical Manufacturing
  • Drug Delivery Systems
  • Additive Manufacturing

Background:

  • Three-dimensional (3D) printing technology presents significant advantages over traditional pharmaceutical manufacturing methods.
  • Advances in 3D printing enable the design of devices for producing formulations with precise drug release characteristics.

Purpose of the Study:

  • To review the diverse applications of 3D printing technology in various drug delivery systems.
  • To highlight the potential of 3D printing for personalized medicine and novel dosage forms.

Main Methods:

  • Summarization of applications across personalized drug dosing, complex drug release profiles, and topical treatments.
  • Exploration of novel dosage forms, drug delivery devices, and 3D printed polypills.

Main Results:

  • 3D printing provides a flexible, layer-by-layer additive manufacturing process for tailored and individualized dosing.
  • The technology allows for accurate dispensing of low volumes with precise spatial control for customized drug delivery.
  • Following FDA approval of the first 3D printed tablet, exploration in drug delivery has intensified.

Conclusions:

  • 3D printing technology has vast potential for designing diverse delivery systems and patient-compatible polypills.
  • The future lies in developing 3D printing systems for manufacturing personalized doses, revolutionizing drug delivery.
  • While promising, the technology requires further evolution to reach its full potential in pharmaceutical applications.