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Understanding how a drug's concentration fluctuates within the body over time is crucial in pharmacokinetics, particularly with multiple oral doses. A graphical representation of multiple oral dosages provides insight into these dynamics. Typical accumulation curves of a drug's concentration in the body reveal a sawtooth pattern, indicating periodic peaks and troughs correlating with each dose administration and the drug's subsequent elimination.The plasma concentration at any time during an...
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A Critical Review on 3D-printed Dosage Forms.

Ilias El Aita1, Hanna Ponsar1,2, Julian Quodbach1

  • 1Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.

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3D-printing offers a promising approach for creating personalized pharmaceutical dosage forms with controlled drug release. This technology enables complex structures and tailored release profiles, revolutionizing drug manufacturing.

Keywords:
3D-printingdrop-on-soliddrug release controlfused filament fabricationindividualized medicinepressure-assisted microsyringeselective laser sinteringstereolithography.

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Area of Science:

  • Pharmaceutical Sciences
  • Biomedical Engineering
  • Materials Science

Background:

  • 3D-printing has advanced significantly in various fields, including pharmaceuticals since the first FDA-approved printed drug in 2015.
  • The technology's ability to create intricate geometries makes it ideal for personalized medicine and customized drug delivery systems.
  • 3D-printing facilitates the development of dosage forms with precisely controlled drug release characteristics.

Purpose of the Study:

  • To provide a comprehensive review of 3D-printing techniques used in pharmaceutical applications.
  • To detail the materials, advantages, and disadvantages associated with each 3D-printing method.
  • To critically evaluate the potential of 3D-printing for precise dose and drug release control.

Main Methods:

  • Literature search using identified keywords.
  • Thorough review of existing research on 3D-printing in pharmaceuticals.
  • Critical analysis of current 3D-printing technologies and their applications.

Main Results:

  • 3D-printing is a rapidly advancing manufacturing process for pharmaceutical dosage forms.
  • The review highlights various 3D-printing techniques applicable to drug manufacturing.
  • Evaluation of dose accuracy and drug release control using 3D-printed medications.

Conclusions:

  • 3D-printing is a viable and promising technology for the future of pharmaceutical manufacturing.
  • The technology allows for significant customization in dosage form design and drug delivery.
  • Further research and critical evaluation are essential for optimizing 3D-printing in pharmaceuticals.