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Updated: Feb 1, 2026

Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions
Published on: July 3, 2025
Visual detection of cancer cells by using in situ grown functional Cu2-xSe/reduced graphene oxide hybrids acting as
Qing Juan Guo1, Zi Yu Pan1, Chen Men2
1Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, P. R. China. zhy2013@swu.edu.cn.
Abstract:
A simple protocol for in situ growth of Cu2-xSe nanoparticles on graphene oxide hybrids (Cu2-xSe/rGO) acting as an efficient nanozyme is developed and thus a sensitive visual detection method of cancer cells is proposed. The Cu2-xSe/rGO heterogeneous nanomaterials have been proven to exhibit high peroxidase-like activity to catalyze the reaction of the peroxidase substrate in the presence of hydrogen peroxide. Herein, we used Cu2-xSe/rGO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells and a total of 63 cancer cells (MCF-7) can be distinguished by naked-eye observation. The results showed that the Cu2-xSe/rGO hybrids could be the promising nanozyme mimetics for potential applications in bioanalytical fields.
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