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The usefulness of selected biomarkers in patients with valve disease

Piotr Duchnowski1, Tomasz Hryniewiecki1, Mariusz Kuśmierczyk2

  • 1Department of Acquired Cardiac Defects, Institute of Cardiology,  Warsaw, Poland.

Biomarkers in Medicine
|December 7, 2018
PubMed

Insights

Biomarkers like high-sensitivity C-reactive protein and red cell distribution width predict poor outcomes in valve surgery patients. These findings aid in assessing risks for patients undergoing cardiac valve procedures.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Surgical Outcomes

Background:

  • Cardiac valve surgery is a critical intervention for significant valve defects.
  • Identifying prognostic factors is essential for optimizing patient management and outcomes.
  • Pre-operative and peri-operative biomarkers may offer valuable predictive information.

Purpose of the Study:

  • To evaluate the prognostic significance of specific biomarkers in patients undergoing valve surgery.
  • To identify predictors of major adverse events within 30 days post-surgery.

Main Methods:

  • A prospective study included 416 consecutive patients undergoing elective valve repair or replacement.
  • The primary endpoint was defined as any major adverse event, including 30-day mortality.
  • Multivariate analysis was employed to identify independent predictors.

Main Results:

  • The composite endpoint occurred in 81 patients (19.5%).
  • High-sensitivity C-reactive protein (hs-CRP), red cell distribution width (RDW), and red blood cell count (RBC) were identified as independent predictors.
  • Elevated hs-CRP (p=0.03), RDW (p=0.0001), and RBC count (p=0.005) were significantly associated with adverse outcomes.

Conclusions:

  • Elevated hs-CRP, RDW, and RBC count are associated with poorer outcomes after valve surgery.
  • These biomarkers can aid in risk stratification for patients undergoing cardiac valve procedures.
  • Further research could explore the clinical utility of these markers in guiding treatment decisions.
Abstract

Keywords:
EuroSCORE IIbiomarkershigh-sensitivity C-reactive proteinpostoperative complicationspredictorsred blood cell countred cell distribution widthrisk stratificationvalve diseasevalve surgery

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