Related Experiment Video

Updated: Feb 1, 2026

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
09:45

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Published on: January 24, 2025

7.0K

Prevalence of macrolide resistance in Treponema pallidum is associated with macrolide consumption

Chris Kenyon1,2

  • 11​HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium.

Journal of Medical Microbiology
|December 7, 2018
PubMed

Insights

Global macrolide consumption strongly correlates with macrolide resistance in Treponema pallidum. Higher antibiotic use in populations is linked to increased resistance, impacting public health strategies.

Area of Science:

  • Microbiology
  • Epidemiology
  • Public Health

Background:

  • Macrolide resistance in Treponema pallidum shows significant global variation.
  • Understanding the drivers of this resistance is crucial for effective treatment and control.

Purpose of the Study:

  • To investigate the relationship between population-level macrolide consumption and the prevalence of macrolide resistance in Treponema pallidum.

Main Methods:

  • A country-level regression analysis was performed.
  • Peak macrolide resistance prevalence was regressed against national macrolide consumption in the preceding year.
  • The year of the resistance prevalence estimate was included as a control variable.

Main Results:

  • A significant positive association was found between per capita macrolide consumption and macrolide resistance.
  • The coefficient was 0.7 (95% CI: 0.2-0.12, P=0.009).

Conclusions:

  • Population-level macrolide consumption is a significant factor contributing to global variations in Treponema pallidum macrolide resistance.
  • This finding has implications for antibiotic stewardship and infectious disease management.
Keywords:
Treponema pallidumantimicrobial resistancemacrolide resistancesyphilis

More Related Videos

Author Spotlight: Influence of Temperature on Drosophila melanogaster and Desert-Adapted Beetles07:12

Author Spotlight: Influence of Temperature on Drosophila melanogaster and Desert-Adapted Beetles

Published on: July 7, 2023

1.9K
A High Throughput Microplate Feeder Assay for Quantification of Consumption in Drosophila08:55

A High Throughput Microplate Feeder Assay for Quantification of Consumption in Drosophila

Published on: June 14, 2021

3.8K

Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.9K
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
Equivalent Resistance01:16

Equivalent Resistance

In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
983
Resistance and Conductance01:25

Resistance and Conductance

A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
513
Rolling Resistance01:21

Rolling Resistance

When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
662