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The Yale Center for Biomedical Innovation and Technology (CBIT): One Model to Accelerate Impact From Academic Health
Alyssa L Siefert1, Malgorzata S Cartiera, Ayesha N Khalid
1A.L. Siefert is engineering director, Yale Center for Biomedical Innovation and Technology (CBIT), and biomedical engineering lecturer, Yale University, New Haven, Connecticut. M.S. Cartiera is investment and innovation director, Yale CBIT and Center for Health Innovation, Yale New Haven Health System, New Haven, Connecticut. A.N. Khalid is clinical director, Yale CBIT, New Haven, Connecticut, and clinical instructor, Harvard Medical School, Boston, Massachusetts. M.C. Nantel is program coordinator, Yale CBIT, New Haven, Connecticut. C.R. Loose is coexecutive director, Yale CBIT, New Haven, Connecticut, and chief scientific officer, Frequency Therapeutics, Cambridge, Massachusetts. P.G. Schulam is cofounder, Yale CBIT, chair of urology, Yale School of Medicine, and faculty director, Tsai Center for Innovative Thinking, Yale University, New Haven, Connecticut. W.M. Saltzman is cofounder, Yale CBIT, and Goizueta Foundation Professor of Biomedical and Chemical Engineering, Yale University, New Haven, Connecticut. M.K. Dempsey is coexecutive director, Yale CBIT, New Haven, Connecticut, and entrepreneur-in-residence, Consortia for Improving Medicine with Innovation & Technology (CIMIT), Boston, Massachusetts.
The Yale Center for Biomedical Innovation and Technology (CBIT) connects clinicians with researchers to accelerate health care innovation. This model enhances translational research, commercializes projects, and improves patient outcomes.
Area of Science:
- Biomedical innovation
- Translational research
- Health care improvement
Background:
- Translating academic biomedical advances into clinical practice is challenging, costly, and poorly understood.
- Clinicians often lack the time/expertise to solve identified health care problems, while researchers may be unaware of clinical needs.
- Bridging this gap is crucial for effective health care innovation.
Purpose of the Study:
- To describe the establishment and impact of the Yale Center for Biomedical Innovation and Technology (CBIT).
- To present CBIT's model as a strategy for accelerating academic medicine's impact on clinical care.
- To offer CBIT's project advising strategy as a template for efficient biomedical innovation.
Main Methods:
- Reviewing other health care innovation centers and adopting best practices.
- Tailoring activities to a unique ecosystem, including courses, clinical immersion, and hackathons.
- Establishing a health care innovation cycle to guide translational research.
Main Results:
- Yale CBIT has engaged over 3,000 individuals and supported over 200 projects.
- Several supported projects have been commercialized, securing millions in follow-on funding.
- The health care innovation cycle has proven an efficient strategy for translational research.
Conclusions:
- The Yale CBIT model effectively accelerates the translation of academic biomedical research into clinical practice.
- The center's approach enhances the impact of health care innovators.
- This model aims to improve patient outcomes and experiences through efficient biomedical innovation.
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