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Association Between Noninfectious Uveitis and Psychological Stress
Elyse J Berlinberg1, John A Gonzales1,2, Thuy Doan1,2
1Francis I. Proctor Foundation, University of California, San Francisco.
JAMA Ophthalmology
|December 7, 2018
Summary
Patients with uveitis experience higher psychological stress, but stress levels do not differ between active and controlled disease. Comprehensive uveitis treatment should address psychological well-being.
Area of Science:
- Ophthalmology
- Immunology
- Psychiatry
Background:
- Uveitis is an ocular immune system disorder.
- The relationship between stress and uveitis is not well understood.
- Stress impacts immune function, warranting investigation into its role in uveitis.
Purpose of the Study:
- To investigate the association between uveitis and psychological stress.
- To compare stress levels in patients with uveitis versus controls.
- To explore stress predictors and cortisol levels in uveitis patients.
Main Methods:
- A cross-sectional, case-control study was conducted.
- Participants included 80 adults with noninfectious uveitis and 40 controls.
- Psychological stress was assessed using the Perceived Stress Scale (PSS-10), and diurnal salivary cortisol was measured.
Main Results:
- Uveitis patients reported significantly higher PSS-10 scores (4.3 points higher) than controls.
- No significant difference in PSS-10 scores was found between active and controlled uveitis.
- Female sex, depression history, and posterior/panuveitis were associated with higher stress in uveitis patients.
Conclusions:
- Patients with uveitis exhibit elevated psychological stress compared to controls.
- Stress levels do not correlate with disease activity (active vs. controlled uveitis).
- Integrated treatment approaches for uveitis should consider psychological support.
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