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Chromatin Modifications in Toxicology.
1Department of Pharmacology and Toxicology, College of Pharmacy , University of Arizona , Tucson , Arizona 85721 , United States.
Chemical Research in Toxicology
|December 7, 2018
Summary
Environmental and chemical exposures can alter cell epigenomics by changing histone modifications. Future toxicogenomic studies should investigate the "Histone Code" to understand these epigenomic changes.
Area of Science:
- Epigenetics and Molecular Biology
- Toxicology
- Metabolomics
Background:
- Histone modifications are crucial regulators of chromatin structure and gene expression.
- Environmental and chemical exposures can influence cellular epigenomic states.
- Metabolites from exposures may mediate changes in histone modifications.
Purpose of the Study:
- To highlight the role of primary and secondary metabolites in shaping the epigenomic state.
- To emphasize the importance of covalent histone modifications in response to exposures.
- To advocate for the characterization of the "Histone Code" in toxicogenomic analyses.
Main Methods:
- Review of existing literature on histone modifications and environmental exposures.
- Analysis of potential mechanisms linking metabolites to histone modifications.
- Conceptual framework for integrating metabolomic and toxicogenomic data.
Main Results:
- Metabolites derived from environmental and chemical exposures can covalently modify histones.
- These modifications can alter chromatin structure and consequently affect cellular function.
- The interplay between metabolites and histone modifications represents a key aspect of the epigenomic response to toxicants.
Conclusions:
- Metabolite-mediated histone modifications are critical in understanding the epigenomic impact of environmental exposures.
- Characterizing the "Histone Code" is essential for advancing toxicogenomic research.
- Future research should focus on elucidating the specific metabolite-histone modification pathways.
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