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Related Concept Videos

Gene Families01:57

Gene Families

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
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Role of Septins01:02

Role of Septins

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Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
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The Role of Culture01:23

The Role of Culture

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Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Gene Flow02:39

Gene Flow

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Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
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Gene Conversion02:08

Gene Conversion

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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Related Experiment Video

Updated: Feb 1, 2026

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
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Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

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CHD2: One Gene, Many Roles.

Vanesa Nieto-Estevez1, Jenny Hsieh1

  • 1Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.

Neuron
|December 7, 2018
PubMed
Summary

Chromodomain helicase DNA-binding 2 (CHD2) gene mutations are linked to neurodevelopmental disorders. New research shows Chd2 haploinsufficiency impairs brain development, synapse function, and memory in mice.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Mutations in the chromodomain helicase DNA-binding 2 (CHD2) gene are associated with various neurodevelopmental disorders.
  • Understanding the precise role of CHD2 in brain development is crucial for diagnosing and treating these conditions.

Purpose of the Study:

  • To investigate the impact of Chd2 haploinsufficiency on cortical development, synaptic function, and memory in a mouse model.
  • To elucidate the molecular mechanisms underlying CHD2's role in neurodevelopment.

Main Methods:

  • Utilized a mouse model with Chd2 haploinsufficiency.
  • Assessed cortical development through histological and molecular analyses.
  • Evaluated synaptic function using electrophysiological recordings.

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  • Tested memory performance through behavioral assays.

    • Main Results:

    • Chd2 haploinsufficiency led to compromised cortical development in mice.
    • Synaptic function was impaired in Chd2-deficient mice.
    • Memory deficits were observed in the studied mouse model.

    Conclusions:

    • Chd2 haploinsufficiency significantly impacts cortical development, synaptic plasticity, and memory formation.
    • These findings highlight the critical role of CHD2 in normal brain function and suggest potential therapeutic targets for CHD2-related neurodevelopmental disorders.