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Related Experiment Video

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Operant Sensation Seeking in the Mouse
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Published on: November 10, 2010

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Hide and seek.

Marta Saint-Gerons1, Silvia Muñoz2, Jurij R Bilyk3

  • 1Department of Ophthalmology, Hospital Universitari Mútua de Terrassa, Barcelona, Spain.

Survey of Ophthalmology
|December 7, 2018
PubMed
Summary
This summary is machine-generated.

This case study highlights a patient with rheumatoid arthritis who also presented with IgG4-related disease, demonstrating overlapping clinical and histopathological features. The findings emphasize the importance of considering IgG4-related disease in rheumatoid arthritis patients with specific visual symptoms.

Keywords:
IgG4-related diseaseoptic neuropathypachymeningitisrheumatoid arthritis

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease primarily affecting joints.
  • Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition characterized by IgG4-positive plasma cell infiltration.

Observation:

  • A 51-year-old woman with a history of RA presented with painless, progressive left eye vision loss.
  • Ophthalmic examination revealed optic disc pallor, and MRI showed pachymeningeal enhancement and left optic nerve hypersignal.
  • Meningeal biopsy confirmed numerous IgG4-positive plasma cells, meeting diagnostic criteria for IgG4-RD.

Findings:

  • The patient's clinical presentation and histopathological findings met diagnostic criteria for both RA and IgG4-RD.
  • This case illustrates a rare instance where RA coexists with and exhibits features consistent with IgG4-RD.

Implications:

  • The co-occurrence suggests a potential link or shared pathway between RA and IgG4-RD.
  • Highlights the need for comprehensive evaluation in RA patients presenting with neurological or ocular symptoms suggestive of IgG4-RD.
  • This case expands the understanding of the spectrum of IgG4-RD and its potential overlap with other autoimmune conditions.