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Chitosan-graft-poly(N-hydroxy ethyl acrylamide) copolymers: Synthesis, characterization and preliminary blood
Ehsan Bahramzadeh1, Elvan Yilmaz1, Terin Adali2
1Department of Chemistry, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta North Cyprus via Mersin 10, Turkey.
International Journal of Biological Macromolecules
|December 7, 2018
Summary
Chitosan-graft-poly(N-hydroxy ethyl acrylamide) surfaces show improved blood compatibility and reduced protein adsorption for biomedical uses. These modified chitosan films exhibit anticoagulant activity, making them promising for medical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Chitosan is a biocompatible polymer with potential in biomedical applications.
- Developing advanced chitosan-based materials with enhanced hemocompatibility is crucial for medical devices and implants.
Purpose of the Study:
- To synthesize and characterize chitosan-graft-poly(N-hydroxy ethyl acrylamide) (polyHEAA) surfaces.
- To evaluate the blood compatibility and protein adsorption properties of the modified chitosan films for biomedical applications.
Main Methods:
- Poly(N-hydroxy ethyl acrylamide) was grafted onto chitosan using potassium persulfate initiator in an acidic medium.
- Products were cross-linked thermally or chemically using methylene bis acrylamide (MBA).
- Characterization involved FTIR, XRD, and SEM; protein adsorption and blood compatibility (PT, APTT, platelet adhesion) were assessed in vitro.
Main Results:
- Chitosan-graft-polyHEAA films demonstrated reduced protein adsorption (30% BSA, 10% HSA removal).
- Films exhibited normal prothrombin time (PT) and activated partial thromboplastin time (APTT) values, indicating good blood compatibility.
- Chitosan-graft-polyHEAA and chitosan-graft-(polyHEAA;MBA) films showed anticoagulant activity and minimal blood component adhesion compared to blank chitosan films.
Conclusions:
- Chitosan-graft-polyHEAA surfaces possess excellent hemocompatibility and reduced protein fouling.
- These modified chitosan materials demonstrate significant potential for use in blood-contacting biomedical applications.
- The study highlights the efficacy of grafting polyHEAA onto chitosan for enhancing its performance in biological environments.
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