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Pharmaceutical cocrystals: from serendipity to design to application
Oisin N Kavanagh1, Denise M Croker1, Gavin M Walker1
1Synthesis and Solid State Pharmaceutical Centre (SSPC), Bernal Institute, University of Limerick, Limerick, Ireland.
Drug Discovery Today
|December 7, 2018
Summary
Pharmaceutical cocrystals offer improved drug properties without sacrificing efficacy. This review highlights marketed cocrystal products, emphasizing their discovery, use, and market success.
Area of Science:
- Pharmaceutical science
- Drug delivery
- Materials science
Background:
- Pharmaceutical cocrystals have gained significant traction since 2003.
- Cocrystal investigations and patent applications have steadily increased.
- Industry interest in cocrystals is heightened due to improved drug properties.
Purpose of the Study:
- To review all marketed drug products utilizing pharmaceutical cocrystal drug substances.
- To emphasize the discovery, rationale for use, and market impact of these cocrystals.
Main Methods:
- Literature review of cocrystal investigations.
- Analysis of patent applications.
- Review of marketed pharmaceutical cocrystal products since 1963.
Main Results:
- The first recorded pharmaceutical cocrystal product was Beta-Chlor® in 1963.
- Four new cocrystal product approvals occurred between 2014 and 2017.
- An enhanced understanding of cocrystal design, characterization, and manufacturing is evident.
Conclusions:
- Pharmaceutical cocrystals represent a significant advancement in drug development.
- Cocrystals improve physicochemical properties without compromising therapeutic benefits.
- The market impact and pipeline of cocrystal products indicate continued growth.
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