[Gangliocytic paragangliomas: a clinicopathologic study]

Area of Science:

• Gastroenterology
• Surgical Pathology
• Oncology

Background:

• Gangliocytic paraganglioma (GP) is a rare tumor typically found in the duodenum.
• Understanding its clinicopathological features is essential for accurate diagnosis and management.

Purpose of the Study:

• To investigate the clinicopathological characteristics of duodenal gangliocytic paraganglioma (GP).
• To evaluate the diagnostic markers and patient outcomes for this rare duodenal tumor.

Main Methods:

• Retrospective analysis of 4 GP cases diagnosed between 2011 and 2017.
• Utilized HE staining and immunohistochemistry (CKpan, Syn, CgA, CD56, NSE, NF, S-100, SOX-10).
• Clinical data and follow-up information were collected via medical records and telephone communication.

Main Results:

• Four patients (2 male, 2 female, median age 56) presented with abdominal pain and distention.
• Tumors were located in the duodenum, measuring 0.6-1.8 cm, involving mucosa and submucosa.
• Microscopically, tumors comprised epithelioid, spindle, and ganglion-like cells with distinct immunohistochemical profiles.
• All patients showed no recurrence after endoscopic excision during a 3-30 month follow-up.

Conclusions:

• Duodenal gangliocytic paraganglioma (GP) is a benign neoplasm with an excellent prognosis following endoscopic resection.
• Consider GP in the differential diagnosis of duodenal mass lesions, particularly those involving the mucosa and submucosa.
• Early diagnosis and appropriate management are key to favorable patient outcomes.