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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Cancer Prevention02:59

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Feb 1, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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OMCD: OncomiR Cancer Database.

Aaron L Sarver1,2, Anne E Sarver3, Ce Yuan3,4

  • 1Institute of Health Informatics, University of Minnesota, Minneapolis, MN, USA. sarver@umn.edu.

BMC Cancer
|December 8, 2018
PubMed
Summary
This summary is machine-generated.

The OncomiR Cancer Database (OMCD) provides a comprehensive resource for analyzing microRNA (miRNA) expression across over 9500 cancer patient samples. This tool aids in understanding pan-cancer miRNA profiles for improved tumor biology insights and biomarker development.

Keywords:
CancerDatabaseOncomiRTCGAmiRNAmiRNA expression profilemicroRNA

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Area of Science:

  • Genomics
  • Cancer Biology
  • Bioinformatics

Background:

  • MicroRNAs (miRNAs) play a critical role in cancer development.
  • miRNA dysregulation is common and cancer-specific, necessitating pan-cancer expression analysis.
  • Understanding pan-cancer miRNA expression is vital for tumor biology and biomarker discovery.

Purpose of the Study:

  • To develop a centralized database for comparative genomic analysis of miRNA sequencing data.
  • To facilitate systematic analysis of miRNA expression across diverse cancer types.
  • To provide a resource for exploring miRNA patterns in relation to clinical information.

Main Methods:

  • Development of the OncomiR Cancer Database (OMCD) hosted on a web server.
  • Integration of miRNA sequencing data from over 9500 cancer patient samples from The Cancer Genome Atlas (TCGA).
  • Inclusion of associated clinical information and TCGA-common organ-specific search functionalities.

Main Results:

  • The OMCD enables simple visualization of TCGA miRNA sequencing data.
  • Statistical analysis of differentially expressed miRNAs for individual cancer types is supported.
  • Exploration of miRNA clusters across different cancer types is facilitated.

Conclusions:

  • The OMCD is freely accessible to all users at www.oncomir.umn.edu/omcd.
  • The database supports visualization, statistical analysis, and exploration of miRNA data.
  • OMCD serves as a valuable tool for cancer research and biomarker development.