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Dendritic cell activation is blunted in patients with coronary artery disease and diabetes mellitus

Gulay Imadoglu Yetkin1, Aysegul Atak Yucel2, İshak Özel Tekin3

  • 1IMC Hospital International Medical Center Division of Microbiology, Mersin, Turkey.

Journal of Diabetes and Its Complications
|December 8, 2018
PubMed

Insights

Dendritic cell (DC) activation by oxidized LDL is blunted in patients with coronary artery disease (CAD), especially those with diabetes mellitus (DM). This suggests impaired immune responses in CAD patients with diabetes.

Area of Science:

  • Immunology
  • Cardiology
  • Metabolic Diseases

Background:

  • Dendritic cells (DCs) are crucial immune cells.
  • Diabetic patients with unstable angina pectoris (UAP) show more mature and activated DCs.
  • Previous findings suggest altered DC function in diabetic cardiovascular disease.

Purpose of the Study:

  • To assess dendritic cell (DC) activation in patients with coronary artery disease (CAD) with and without diabetes mellitus (DM).
  • To compare DC activation in these groups to subjects with normal coronary arteries (NCA).

Main Methods:

  • Peripheral blood DCs from 23 severe CAD patients and 6 NCA subjects were analyzed.
  • DC activation was measured using flow cytometry for CD86 expression.
  • Cells were stimulated with oxidized low-density lipoprotein (ox-LDL).

Main Results:

  • DC activation by ox-LDL was significantly increased in CAD patients without DM compared to controls.
  • However, DC activation was not significantly increased in CAD patients with DM.
  • NCA subjects without DM showed marked CD86 activation after ox-LDL stimulation.

Conclusions:

  • DC activation upon ox-LDL stimulation is blunted in CAD patients compared to NCA subjects.
  • This defective DC activation is more pronounced in diabetic patients with CAD.
  • Impaired DC function may contribute to the pathophysiology of CAD in diabetic individuals.
Abstract

Keywords:
AtherosclerosisCD86Coronary artery diseaseDendritic cellsDiabetes mellitus

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