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Updated: Feb 1, 2026

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
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5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction

Xiao Ding1, Luigi Piero Stasi1, Xuedong Dai1

  • 1Neurodegeneration DPU, Neurosciences Therapeutic Area Unit, GSK Pharmaceuticals R&D, 898 Halei Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, PR China.

Bioorganic & Medicinal Chemistry Letters
|December 8, 2018
PubMed

Keywords:
CNS penetrationLRRK2PFIParkinson’s diseaseUnbound fraction

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