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Systemic network for dietary inorganic phosphate adaptation among three organs
Kayo Ikuta1, Hiroko Segawa2, Ai Hanazaki1
1Department of Molecular Nutrition, Institute of Biomedical Sciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima City, 770-8503, Japan.
Pflugers Archiv : European Journal of Physiology
|December 8, 2018
Summary
Salivary glands regulate phosphate (Pi) levels through the Npt2b protein, which responds to dietary Pi. This highlights salivary Pi secretion
Area of Science:
- Physiology
- Mineral Metabolism
- Homeostasis
Background:
- Inorganic phosphate (Pi) is crucial for biological processes.
- Salivary glands and diet are primary sources of Pi.
- Mechanisms regulating salivary Pi homeostasis remain unclear.
Purpose of the Study:
- To investigate the regulation of salivary Pi concentrations by dietary Pi.
- To elucidate the role of Npt2b in salivary Pi homeostasis.
Main Methods:
- Utilized mouse models with dietary Pi manipulation.
- Analyzed Npt2b protein levels in salivary gland ductal cells.
- Examined Npt2b endocytosis and function in global and intestine-specific knockout mice.
Main Results:
- Dietary Pi significantly altered Npt2b protein levels in salivary glands.
- High-Pi diet induced rapid Npt2b endocytosis and increased salivary Pi.
- Npt2b deficiency in mice led to altered salivary Pi concentrations.
Conclusions:
- Salivary gland Npt2b levels are regulated by dietary Pi and impact salivary Pi concentration.
- Intestinal Npt2b may also influence salivary Pi and renal Pi excretion.
- Salivary Pi secretion contributes to endogenous Pi recycling alongside intestinal absorption and renal excretion.
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