Animal models and the study of atherosclerosis

Identifications, requirements, and numerous contributions of animal models, as well as different aspects of atherosclerosis that were successfully studied in animals, are reviewed. Suggestions are made for updating the selection of specific animal models that will most satisfactorily fulfill the needs of studies in a particular problem of this disease process. Attention has been called to the importance of the type of atherosclerotic lesions and their dependence on species susceptibility and dietary influence. The role the type of lesion plays in atherosclerosis has been emphasized, especially in studies concerned with the progression and therapy of this disease process. From the variety of animals listed in this review, as well as the number of different problems already studied or awaiting further study, it appears that numerous data can be reconciled to help elucidate many problems and provide information for our better understanding of atherosclerosis. This, in turn, will allow us to make more accurate and effective recommendations leading to prevention and/or treatment of atherosclerosis.