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Molecular Mechanisms of Early and Late LTP
Saltuk Bugra Baltaci1, Rasim Mogulkoc1, Abdulkerim Kasim Baltaci2
1Faculty of Medicine, Department of Physiology, Selcuk University, 42031, Konya, Turkey.
Abstract:
LTP is the most intensively studied cellular model of the memory and generally divided at least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates biochemical events and trafficking of proteins, which eventually potentiate synaptic transmission, and is independent of de novo protein synthesis. In contrast, L-LTP requires gene expression and local protein synthesis regulated via TrkB receptor- and functional prions CPEB2-3-mediated translation. Maintenance of LTP for longer periods depends on constitutively active PKMζ. Throughout this review, current knowledge about early and late phases of LTP will be reviewed.
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