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Isolation and Purification of Murine Cardiac Pericytes
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Ca2+ Signalling in Pericytes.

Theodor Burdyga1, Lyudmyla Borysova2

  • 1Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. burdyga@liv.ac.uk.

Advances in Experimental Medicine and Biology
|December 8, 2018
PubMed
Summary
This summary is machine-generated.

Pericytes and myocytes regulate microcirculation via calcium (Ca2+) signaling. This study compares Ca2+ signaling and contractile roles of pericytes versus myocytes in various tissues.

Keywords:
Ca2+ oscillationsCa2+ signallingCa2+ waveCapillariesConducted vasoconstrictionConducted vasodilationGap junctionsMicrovascular networksPericytesPostcapillary venulesPrecapillary arteriolesVasoconstriction

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Area of Science:

  • Physiology
  • Cell Biology
  • Cardiovascular Research

Background:

  • Microcirculation involves arterioles, capillaries, and venules, with myocytes and pericytes playing distinct roles.
  • Pericytes are crucial microvascular cells situated at the blood-interstitial space interface.
  • Physiological differences suggest unique functional roles for pericytes and myocytes in local blood flow regulation.

Purpose of the Study:

  • To summarize Ca2+ signaling in pericytes, focusing on their contractile functions.
  • To compare Ca2+ signaling and contractile responses between pericytes and myocytes.
  • To investigate Ca2+ sources, release, and entry mechanisms in pericytes.

Main Methods:

  • Literature review on Ca2+ signaling in pericytes.
  • Analysis of Ca2+ signaling and contractile roles in different tissues.
  • Comparison of pericyte and myocyte Ca2+ dynamics and responses.

Main Results:

  • Pericytes and myocytes exhibit distinct physiological responses to vasoactive molecules.
  • Ca2+ signaling controls the contractile activity of both pericytes and myocytes.
  • Mechanisms of Ca2+ release and entry influence spatio-temporal Ca2+ signals in pericytes.

Conclusions:

  • Pericytes have unique roles in microcirculation, differing from myocytes.
  • Understanding Ca2+ signaling in pericytes is key to their contractile function.
  • Pericyte Ca2+ signaling varies across different microcirculatory beds and organs.