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Pericytes in Tissue Engineering

Betül Çelebi-Saltik1,2

  • 1Department of Stem Cell Sciences, Hacettepe University Graduate School of Health Sciences, Ankara, Turkey. betul.celebi@hacettepe.edu.tr.

Advances in Experimental Medicine and Biology
|December 8, 2018
PubMed

Insights

Pericytes are versatile cells crucial for tissue repair and regeneration. Their unique properties make them ideal for developing advanced tissue engineering strategies in regenerative medicine.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cell Biology

Background:

  • Pericytes play vital roles in blood-brain barrier integrity, vascular stability, and stem cell maintenance.
  • Pericytes exhibit multipotent differentiation capacity, similar to mesenchymal stem cells (MSCs).

Purpose of the Study:

  • To explore the application of pericytes in tissue engineering for regenerative medicine.
  • To highlight the advantages of pericytes in creating advanced tissue-engineered models.

Main Methods:

  • Isolation of pericytes from fetal and adult tissues.
  • Utilizing pericytes in three-dimensional (3D) tissue-engineered systems.
  • Comparing 3D systems with traditional monolayer cultures.

Main Results:

  • Pericytes possess properties suitable for tissue engineering applications.
  • Tissue-engineered 3D systems better mimic in vivo environments compared to 2D cultures.
  • Pericyte-based models offer ethical and cost-effective alternatives to animal models.

Conclusions:

  • Pericytes are promising cell candidates for regenerative medicine applications.
  • Tissue engineering utilizing pericytes can advance the development of functional tissues.
  • 3D pericyte-based models represent a significant step forward in regenerative medicine research.

Keywords:
Blood tissue engineeringBone tissue engineeringCardiac tissue engineeringCartilage tissue engineeringDermal tissue engineeringHematopoietic stem cellsMesenchymal stem cellsNichePericytesScaffoldTissue engineeringVascular tissue engineering

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