Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Feb 1, 2026

Isolation and Purification of Murine Cardiac Pericytes

Isolation and Purification of Murine Cardiac Pericytes

Published on: August 16, 2019

Pericyte Secretome.

Abderahim Gaceb¹, Gesine Paul^2,3

¹Translational Neurology Group, Department of Clinical Sciences and Wallenberg Center for Molecular Medicine, Department of Neurology, Lund University, Lund, Sweden.

Advances in Experimental Medicine and Biology

|December 8, 2018

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

STING-dependent peripheral inflammaging drives neurodegeneration via extracellular vesicles.

Cell reports·2026

Same author

Agreement between relatives of Parkinson's patients and clinical observer in home diary assessments.

Journal of Parkinson's disease·2026

Same author

Neuroinflammation and neurodegeneration trigger a specific splice form of ribosomal protein S24.

Brain : a journal of neurology·2026

Same author

STEM-PD trial protocol: a multi-centre, single-arm, first-in-human, dose-escalation trial, investigating the safety and tolerability of intraputamenal transplantation of human embryonic stem cell-derived dopaminergic cells for Parkinson's disease.

BMJ open·2025

Same author

Isolated dyslipidemia triggers early kidney injury through fibrotic remodeling, subcellular lipid accumulation, and AMPK overexpression.

Ultrastructural pathology·2025

Same author

Mapping the distribution of neurotransmitters to resting-state functional connectivity in Parkinson's disease.

Brain communications·2025

Pericytes, cells at the blood-tissue interface, secrete diverse molecules influencing inflammation, immunity, and tissue repair. Their complex secretome offers potential for future regenerative medicine applications.

Area of Science:

Cell biology
Tissue engineering
Immunology

Background:

Pericytes are crucial for blood-brain barrier maintenance, angiogenesis, and regulating blood flow.
Emerging evidence highlights pericytes' broader roles beyond established functions.
Their unique position allows them to sense and respond to microenvironmental changes.

Purpose of the Study:

To review the diverse secretory properties of pericytes.
To explore how pericyte secretomes change in response to various pathological stimuli.
To elucidate the implications of pericyte secretion in physiological and pathological conditions.

Main Methods:

Literature review of studies on pericyte secretomes.
Analysis of pericyte responses to stimuli like inflammation, hypoxia, and high glucose.

Keywords:

Angiogenesis Blood-brain barrier Chemokines Cytokines Growth factor Inflammation Microvesicles Pericytes Regeneration Secretome

More Related Videos

Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization

Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization

Published on: October 20, 2019

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

Related Experiment Videos

Last Updated: Feb 1, 2026

Isolation and Purification of Murine Cardiac Pericytes

Isolation and Purification of Murine Cardiac Pericytes

Published on: August 16, 2019

Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization

Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization

Published on: October 20, 2019

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

Synthesis of data on tissue-specific and stimulus-specific pericyte secretions.

Main Results:

Pericytes secrete a wide array of molecules, including inflammatory factors, growth factors, and extracellular matrix components.
The secretome is highly specific to the tissue and the inducing stimulus.
Pericyte secretions play roles in immune responses, tumor immune evasion, and tissue homeostasis.

Conclusions:

Pericyte secretomes are critical regulators of tissue function and immune responses.
Understanding pericyte secretory behavior is key to addressing diseases involving inflammation and tissue repair.
Exploiting pericyte secretomes holds promise for regenerative medicine strategies.